{"id":10045,"date":"2026-08-03T11:57:33","date_gmt":"2026-08-03T09:57:33","guid":{"rendered":"https:\/\/www.hitec-zang.de\/?p=10045"},"modified":"2026-08-06T13:18:39","modified_gmt":"2026-08-06T11:18:39","slug":"neues-produkt-fuer-praezise-zellanalysen-unter-kontrollierten-flussbedingungen-patchflux-ai","status":"publish","type":"post","link":"https:\/\/www.hitec-zang.de\/en\/neues-produkt-fuer-praezise-zellanalysen-unter-kontrollierten-flussbedingungen-patchflux-ai\/","title":{"rendered":"Neu: PatchFlux AI\u2122 f\u00fcr pr\u00e4zise Zellanalysen unter kontrollierten Flussbedingungen"},"content":{"rendered":"<div data-elementor-type=\"wp-post\" data-elementor-id=\"10045\" class=\"elementor elementor-10045\" data-elementor-post-type=\"post\">\n\t\t\t\t<div class=\"elementor-element elementor-element-29d723f e-flex e-con-boxed e-con e-parent\" data-id=\"29d723f\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-6d05955f elementor-widget elementor-widget-text-editor\" data-id=\"6d05955f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><\/p>\n<p class=\"wp-block-paragraph\">In einem Verbundprojekt wurde das PatchFlux AI entwickelt. Ein mikrofluidisches System, das speziell daf\u00fcr entwickelt wurde, Zellen unter definierten Flussbedingungen pr\u00e4zise zu untersuchen. Forschende k\u00f6nnen Scherspannung, Temperatur, pH-Wert und Medienwechsel exakt steuern und so physiologische oder pathologische Bedingungen realit\u00e4tsnah nachbilden.<\/p>\n<p><\/p>\n<p class=\"wp-block-paragraph\">Thanks to the integrated high-precision thermostat, the temperature remains stable even during long-term experiments. Shear profiles, exposure duration, and media exchange can all be set via software control and reproduced consistently. This makes PatchFlux AI especially suitable for studies on:<\/p>\n<p><\/p>\n<ul class=\"wp-block-list\">\n<li style=\"list-style-type: none;\">\n<ul class=\"wp-block-list\"><\/ul>\n<\/li>\n<\/ul>\n<p>\u00a0<\/p>\n<ul class=\"wp-block-list\">\n<li style=\"list-style-type: none;\">\n<ul class=\"wp-block-list\">\n<li>Erythrocyte deformability and membrane mechanics<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p><\/p>\n<ul class=\"wp-block-list\">\n<li style=\"list-style-type: none;\">\n<ul class=\"wp-block-list\">\n<li>Osmotic fragility<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p><\/p>\n<ul class=\"wp-block-list\">\n<li style=\"list-style-type: none;\">\n<ul class=\"wp-block-list\">\n<li>Cell adhesion under flow<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p><\/p>\n<ul class=\"wp-block-list\">\n<li style=\"list-style-type: none;\">\n<ul class=\"wp-block-list\">\n<li>RBC shape analysis and aggregation<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p><\/p>\n<ul class=\"wp-block-list\">\n<li style=\"list-style-type: none;\">\n<ul class=\"wp-block-list\">\n<li>Patch-clamp under controlled flow conditions<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p><\/p>\n<ul class=\"wp-block-list\">\n<li style=\"list-style-type: none;\">\n<ul class=\"wp-block-list\">\n<li>Pharmacological responses, dose-response relationships, and reversibility<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p><\/p>\n<p><\/p>\n<p class=\"wp-block-paragraph\">\u00a0<\/p>\n<p>Zuletzt hat die Fachhochschule Aachen zusammen mit HITEC ZANG einige Experimente zur Quantifizierung osmotischer Fragilit\u00e4t bei roten Blutk\u00f6rperchen durchgef\u00fchrt.<\/p>\n<p><\/p>\n<p class=\"wp-block-paragraph\">Das Team untersuchte, wie Aquaporine (AQP) die osmotische Fragilit\u00e4t roter Blutk\u00f6rperchen beeinflussen. Mithilfe des PatchFlux AI\u00a0 verglichen sie zwei Modulatoren (HgCl\u2082 und LPS) und stellten ihren neuen durchflussbasierten Ansatz der klassischen Methode zur Messung der osmotischen Fragilit\u00e4t gegen\u00fcber. Die Ergebnisse sprechen f\u00fcr sich: PatchFlux AI liefert pr\u00e4zise, robuste Messungen und bietet durch seine propriet\u00e4re, KI-gest\u00fctzte Suite zur Analyse und \u00dcberwachung der Erythrozytenform zus\u00e4tzliche Einblicke.<\/p>\n<p>\u00a0<\/p>\n<p><\/p>\n<figure class=\"wp-block-image size-large\"><img fetchpriority=\"high\" decoding=\"async\" width=\"1024\" height=\"578\" class=\"wp-image-10191\" src=\"https:\/\/www.hitec-zang.de\/wp-content\/uploads\/2026\/08\/Paper-Diagramm-1024x578.png\" alt=\"| \u2013 F\u00fchrender Anbieter f\u00fcr Laborreaktoren in der chemischen Verfahrenstechnik\" title=\"| \u2013 F\u00fchrender Anbieter f\u00fcr Laborreaktoren in der chemischen Verfahrenstechnik\" srcset=\"https:\/\/www.hitec-zang.de\/wp-content\/uploads\/2026\/08\/Paper-Diagramm-1024x578.png 1024w, https:\/\/www.hitec-zang.de\/wp-content\/uploads\/2026\/08\/Paper-Diagramm-300x169.png 300w, https:\/\/www.hitec-zang.de\/wp-content\/uploads\/2026\/08\/Paper-Diagramm-768x434.png 768w, https:\/\/www.hitec-zang.de\/wp-content\/uploads\/2026\/08\/Paper-Diagramm-18x10.png 18w, https:\/\/www.hitec-zang.de\/wp-content\/uploads\/2026\/08\/Paper-Diagramm.png 1500w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/>\n<p>\u00a0<\/p>\n<figcaption class=\"wp-element-caption\">Non-parametric Bland\u2013Altman plot comparing MCF\u2085\u2080 values obtained from the flow chamber and classical osmotic fragility methods. Points represent individual paired measurements (4 donors\u2009\u00d7\u20096 occasions) and are color-coded by donor. The y-axis represents the difference in MCF\u2085\u2080 values (Flow Chamber\u2014Classical), while the x-axis shows the average of the two methods. The solid red line indicates the median bias (\u2212\u20090.013), and the blue lines represent the 2.5th and 97.5th percentiles of the differences (\u2212\u20090.055 and 0.030, respectively), serving as non-parametric limits of agreement.)<\/figcaption>\n<\/figure>\n<p><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-096d830 e-con e-atomic-element e-flexbox-base\" data-id=\"096d830\" data-element_type=\"e-flexbox\" data-e-type=\"e-flexbox\">\n\t\t<div data-dce-background-image-url=\"https:\/\/www.hitec-zang.de\/wp-content\/uploads\/2024\/09\/cb9c62625e3596e75b706503758f5de8.svg\" class=\"elementor-element elementor-element-94e78cd e-flex e-con-boxed e-con e-parent\" data-id=\"94e78cd\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-5945c12 e-con-full e-flex e-con e-child\" data-id=\"5945c12\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-f41e9bb elementor-widget elementor-widget-heading\" data-id=\"f41e9bb\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">From Research<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3ffd6cc elementor-widget elementor-widget-text-editor\" data-id=\"3ffd6cc\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>A novel AI-coupled flow chamber method quantifying erythrocyte osmotic fragility<\/strong><\/p>\n<p><em>IPEK SEDA Firat, \u00d6zg\u00fcr Alacayir, Till Kreutz et al. \u2022 <\/em>Scientific Reports 16 \u2022 2026<\/p>\n<p>DOI: <a href=\"https:\/\/doi.org\/10.1038\/s41598-026-38322-z\" target=\"_blank\" rel=\"noopener\">10.1038\/s41598-026-38322-z<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>In einem Verbundprojekt wurde das PatchFlux AI entwickelt. Ein mikrofluidisches System, das speziell daf\u00fcr entwickelt wurde, Zellen unter definierten Flussbedingungen pr\u00e4zise zu untersuchen. Forschende k\u00f6nnen Scherspannung, Temperatur, pH-Wert und Medienwechsel exakt steuern und so physiologische oder pathologische Bedingungen realit\u00e4tsnah nachbilden. Dank des integrierten Hochpr\u00e4zisions-Thermostats bleibt die Temperatur auch in Langzeitversuchen stabil. Scherprofile, Expositionsdauer und Medienwechsel [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":8648,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[21,17],"tags":[],"class_list":["post-10045","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-zellkultur-und-fermentersysteme","category-automatisierung"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.hitec-zang.de\/en\/wp-json\/wp\/v2\/posts\/10045","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hitec-zang.de\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hitec-zang.de\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hitec-zang.de\/en\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hitec-zang.de\/en\/wp-json\/wp\/v2\/comments?post=10045"}],"version-history":[{"count":10,"href":"https:\/\/www.hitec-zang.de\/en\/wp-json\/wp\/v2\/posts\/10045\/revisions"}],"predecessor-version":[{"id":10218,"href":"https:\/\/www.hitec-zang.de\/en\/wp-json\/wp\/v2\/posts\/10045\/revisions\/10218"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.hitec-zang.de\/en\/wp-json\/wp\/v2\/media\/8648"}],"wp:attachment":[{"href":"https:\/\/www.hitec-zang.de\/en\/wp-json\/wp\/v2\/media?parent=10045"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hitec-zang.de\/en\/wp-json\/wp\/v2\/categories?post=10045"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hitec-zang.de\/en\/wp-json\/wp\/v2\/tags?post=10045"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}