{"id":6324,"date":"2025-06-18T09:38:14","date_gmt":"2025-06-18T07:38:14","guid":{"rendered":"https:\/\/www.hitec-zang.de\/?p=6324"},"modified":"2025-08-14T13:33:36","modified_gmt":"2025-08-14T11:33:36","slug":"kooperation-mit-magritek-automatisierte-optimierung-einer-knoevenagel-kondensation-im-mikroreaktorsystem","status":"publish","type":"post","link":"https:\/\/www.hitec-zang.de\/en\/kooperation-mit-magritek-automatisierte-optimierung-einer-knoevenagel-kondensation-im-mikroreaktorsystem\/","title":{"rendered":"Cooperation with Magritek: Automated optimization of a Knoevenagel condensation in a microreactor system"},"content":{"rendered":"<p class=\"wp-block-paragraph\"><br><\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Automation and real-time analytics meet optimization algorithms<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Recent advances in laboratory automation and analytical instrumentation have created new opportunities to accelerate reaction development, particularly in flow chemistry. In a newly published application note, we join forces with Magritek to present a self-optimizing microreaction system. In this note, we combine the intelligent process control of our LabManager and LabVision automation tools with real-time analytics in the form of the Spinsolve Ultra benchtop NMR and an Ehrfeld micro-reaction system. We then used this system to optimize a Knoevenagel condensation step by step while continuously monitoring and adjusting the reaction conditions.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>The result:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Automated self-optimization of Knoevenagel condensation with Bayesian optimization<\/li>\n\n\n\n<li>The system iteratively determines reaction parameters with ever-increasing yields without human intervention.<\/li>\n\n\n\n<li>Demonstration of a fully automated reactor system that optimizes target parameters with minimal effort<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">You want to delve deeper into the subject matter and see how we build a modular MRS from <a href=\"https:\/\/www.ehrfeld.com\/l%C3%B6sungen-f%C3%BCr-die-produktion\" target=\"_blank\" rel=\"noopener\">Ehrfeld<\/a> with automation from HITEC ZANG and a <a href=\"https:\/\/magritek.com\/\" target=\"_blank\" rel=\"noopener\">Magritek<\/a> benchtop NMR spectrometers successfully combined? The full application note, including details of the Knoevagel condensation experiment, can be found here: <\/p>\n\n\n\n<div data-wp-interactive=\"core\/file\" class=\"wp-block-file\"><object data-wp-bind--hidden=\"!state.hasPdfPreview\" hidden class=\"wp-block-file__embed\" data=\"https:\/\/www.hitec-zang.de\/wp-content\/uploads\/2025\/06\/AppNote_HITEC-ZANG-Magritek_06-2025.pdf\" type=\"application\/pdf\" style=\"width:100%;height:600px\" aria-label=\"Embed of AppNote_HITEC-ZANG-Magritek_06-2025.\"><\/object><a id=\"wp-block-file--media-c73799ed-9b34-4b87-a945-af57853d079b\" href=\"https:\/\/www.hitec-zang.de\/wp-content\/uploads\/2025\/06\/AppNote_HITEC-ZANG-Magritek_06-2025.pdf\">AppNote_HITEC-ZANG-Magritek_06-2025<\/a><a href=\"https:\/\/www.hitec-zang.de\/wp-content\/uploads\/2025\/06\/AppNote_HITEC-ZANG-Magritek_06-2025.pdf\" class=\"wp-block-file__button wp-element-button\" aria-describedby=\"wp-block-file--media-c73799ed-9b34-4b87-a945-af57853d079b\" download>Herunterladen<\/a><\/div>","protected":false},"excerpt":{"rendered":"<p>Automatisierung &amp; Echtzeitanalytik treffen auf Optimierungsalgorithmen Die j\u00fcngsten Fortschritte in der Laborautomatisierung und der analytischen Instrumentierung haben neue M\u00f6glichkeiten zur Beschleunigung der Reaktionsentwicklung geschaffen. Insbesondere in der Flow Chemistry. In einer frisch ver\u00f6ffentlichen Application Note stellen wir zusammen mit Magritek ein selbstoptimierendes Mikroreaktionssystem vor. In diesem kombinieren wir intelligente Prozesssteuerung unserer LabManager und LabVision-Automatisierungstools mit [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":6347,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[1],"tags":[43,42,41,44],"class_list":["post-6324","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized","tag-flow-chemistry","tag-knoevenagel-kondensation","tag-magritek","tag-mirkoreaktion"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.hitec-zang.de\/en\/wp-json\/wp\/v2\/posts\/6324","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hitec-zang.de\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hitec-zang.de\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hitec-zang.de\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hitec-zang.de\/en\/wp-json\/wp\/v2\/comments?post=6324"}],"version-history":[{"count":7,"href":"https:\/\/www.hitec-zang.de\/en\/wp-json\/wp\/v2\/posts\/6324\/revisions"}],"predecessor-version":[{"id":6605,"href":"https:\/\/www.hitec-zang.de\/en\/wp-json\/wp\/v2\/posts\/6324\/revisions\/6605"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.hitec-zang.de\/en\/wp-json\/wp\/v2\/media\/6347"}],"wp:attachment":[{"href":"https:\/\/www.hitec-zang.de\/en\/wp-json\/wp\/v2\/media?parent=6324"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hitec-zang.de\/en\/wp-json\/wp\/v2\/categories?post=6324"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hitec-zang.de\/en\/wp-json\/wp\/v2\/tags?post=6324"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}