Automation and real-time analytics meet optimization algorithms
Recent advances in laboratory automation and analytical instrumentation have created new opportunities to accelerate reaction development, particularly in flow chemistry. In a newly published application note, we join forces with Magritek to present a self-optimizing microreaction system. In this note, we combine the intelligent process control of our LabManager and LabVision automation tools with real-time analytics in the form of the Spinsolve Ultra benchtop NMR and an Ehrfeld micro-reaction system. We then used this system to optimize a Knoevenagel condensation step by step while continuously monitoring and adjusting the reaction conditions.
The result:
- Automated self-optimization of Knoevenagel condensation with Bayesian optimization
- The system iteratively determines reaction parameters with ever-increasing yields without human intervention.
- Demonstration of a fully automated reactor system that optimizes target parameters with minimal effort
You want to delve deeper into the subject matter and see how we build a modular MRS from Ehrfeld with automation from HITEC ZANG and a Magritek benchtop NMR spectrometers successfully combined? The full application note, including details of the Knoevagel condensation experiment, can be found here: